:root{--bg-app:#0f0e17;--bg-primary:#1a1823;--bg-secondary:#232135;--bg-tertiary:#2d2a3d;--bg-hover:#353247;--bg-active:#3d3a52;--text-primary:#e8e6f0;--text-secondary:#b4b0c8;--text-muted:#6e6a86;--text-disabled:#4a4760;--text-inverse:#0f0e17;--accent-primary:#6366f1;--accent-primary-hover:#7c3aed;--accent-primary-active:#5b21b6;--accent-secondary:#8b5cf6;--accent-tertiary:#a78bfa;--status-success:#10b981;--status-success-bg:rgba(16,185,129,0.12);--status-success-border:rgba(16,185,129,0.3);--status-warning:#f59e0b;--status-warning-bg:rgba(245,158,11,0.12);--status-warning-border:rgba(245,158,11,0.3);--status-error:#ef4444;--status-error-bg:rgba(239,68,68,0.12);--status-error-border:rgba(239,68,68,0.3);--status-info:#06b6d4;--status-info-bg:rgba(6,182,212,0.12);--status-info-border:rgba(6,182,212,0.3);--entity-gene:#10b981;--entity-gene-bg:rgba(16,185,129,0.12);--entity-gene-border:rgba(16,185,129,0.3);--entity-protein:#a78bfa;--entity-protein-bg:rgba(167,139,250,0.12);--entity-protein-border:rgba(167,139,250,0.3);--entity-molecule:#06b6d4;--entity-molecule-bg:rgba(6,182,212,0.12);--entity-molecule-border:rgba(6,182,212,0.3);--entity-pathway:#14b8a6;--entity-pathway-bg:rgba(20,184,166,0.12);--entity-pathway-border:rgba(20,184,166,0.3);--entity-drug:#f59e0b;--entity-drug-bg:rgba(245,158,11,0.12);--entity-drug-border:rgba(245,158,11,0.3);--entity-disease:#ef4444;--entity-disease-bg:rgba(239,68,68,0.12);--entity-disease-border:rgba(239,68,68,0.3);--entity-tissue:#ec4899;--entity-tissue-bg:rgba(236,72,153,0.12);--entity-tissue-border:rgba(236,72,153,0.3);--entity-trial:#3b82f6;--entity-trial-bg:rgba(59,130,246,0.12);--entity-trial-border:rgba(59,130,246,0.3);--border-primary:#3a3650;--border-secondary:#4a4760;--border-tertiary:#5a5570;--border-focus:var(--accent-primary);--font-sans:"Inter",-apple-system,BlinkMacSystemFont,"Segoe UI",Roboto,sans-serif;--font-mono:"Cascadia Code","SF Mono",Consolas,"Liberation Mono",Menlo,monospace;--font-display:"Inter",-apple-system,BlinkMacSystemFont,sans-serif;--font-display:2rem;--font-h1:1.5rem;--font-h2:1.25rem;--font-h3:1.125rem;--font-body:0.9375rem;--font-sm:0.875rem;--font-xs:0.75rem;--font-code:0.875rem;--font-weight-regular:400;--font-weight-medium:500;--font-weight-semibold:600;--font-weight-bold:700;--line-height-tight:1.25;--line-height-normal:1.5;--line-height-relaxed:1.625;--line-height-loose:2;--letter-spacing-tight:-0.01em;--letter-spacing-normal:0;--letter-spacing-wide:0.025em;--letter-spacing-wider:0.05em;--spacing-0:0;--spacing-1:0.25rem;--spacing-2:0.5rem;--spacing-3:0.75rem;--spacing-4:1rem;--spacing-5:1.25rem;--spacing-6:1.5rem;--spacing-8:2rem;--spacing-10:2.5rem;--spacing-12:3rem;--spacing-16:4rem;--spacing-20:5rem;--spacing-24:6rem;--radius-xs:0.25rem;--radius-sm:0.375rem;--radius-md:0.5rem;--radius-lg:0.75rem;--radius-xl:1rem;--radius-2xl:1.5rem;--radius-full:9999px;--shadow-xs:0 1px 2px 0 rgba(0,0,0,0.3);--shadow-sm:0 1px 3px 0 rgba(0,0,0,0.4),0 1px 2px -1px rgba(0,0,0,0.4);--shadow-md:0 4px 6px -1px rgba(0,0,0,0.4),0 2px 4px -2px rgba(0,0,0,0.4);--shadow-lg:0 10px 15px -3px rgba(0,0,0,0.5),0 4px 6px -4px rgba(0,0,0,0.5);--shadow-xl:0 20px 25px -5px rgba(0,0,0,0.5),0 8px 10px -6px rgba(0,0,0,0.5);--shadow-2xl:0 25px 50px -12px rgba(0,0,0,0.6);--shadow-inner:inset 0 2px 4px 0 rgba(0,0,0,0.3);--glow-primary:0 0 20px rgba(99,102,241,0.4);--glow-success:0 0 20px rgba(16,185,129,0.4);--glow-warning:0 0 20px rgba(245,158,11,0.4);--glow-error:0 0 20px rgba(239,68,68,0.4);--duration-instant:0.1s;--duration-fast:0.15s;--duration-normal:0.25s;--duration-slow:0.3s;--duration-slower:0.4s;--ease-standard:cubic-bezier(0.4,0,0.2,1);--ease-decelerate:cubic-bezier(0.0,0,0.2,1);--ease-accelerate:cubic-bezier(0.4,0,1,1);--ease-bounce:cubic-bezier(0.68,-0.55,0.265,1.55);--transition-fast:var(--duration-fast) var(--ease-standard);--transition-normal:var(--duration-normal) var(--ease-standard);--transition-slow:var(--duration-slow) var(--ease-standard);--touch-target:44px;--touch-target-sm:36px;--touch-target-lg:56px;--container-sm:640px;--container-md:768px;--container-lg:1024px;--container-xl:1280px;--container-2xl:1536px;--sidebar-width:280px;--sidebar-collapsed:64px;--header-height:64px;--header-height-mobile:56px;--input-min-height:44px;--input-max-height:160px;--z-base:0;--z-header:50;--z-input:30;--z-floating:40;--z-kg-bar:25;--z-sidebar:100;--z-sidebar-overlay:99;--z-dropdown:70;--z-modal:110;--z-toast:120;--z-tooltip:130;--breakpoint-xs:480px;--breakpoint-sm:640px;--breakpoint-md:768px;--breakpoint-lg:1024px;--breakpoint-xl:1280px;--breakpoint-2xl:1536px;--opacity-disabled:0.4;--opacity-muted:0.6;--opacity-hover:0.8;--opacity-full:1;--backdrop-blur-sm:blur(4px);--backdrop-blur-md:blur(8px);--backdrop-blur-lg:blur(12px);--backdrop-blur-xl:blur(16px)}@media (prefers-contrast:high){:root{--border-primary:#6e6a86;--border-secondary:#8a86a0;--text-secondary:#d0cee0}}@media (prefers-reduced-motion:reduce){:root{--duration-instant:0.01s;--duration-fast:0.01s;--duration-normal:0.01s;--duration-slow:0.01s;--duration-slower:0.01s}}@media (max-width:767px){:root{--font-display:1.75rem;--font-h1:1.375rem;--font-h2:1.125rem;--font-h3:1rem;--font-body:0.875rem;--font-sm:0.8125rem;--font-xs:0.6875rem;--font-code:0.8125rem}}