:root{--bg-app:#0b0f14;--bg-primary:#111827;--bg-secondary:#1a2234;--bg-tertiary:#243044;--bg-hover:#2d3b52;--bg-active:#374863;--text-primary:#e2e8f0;--text-secondary:#c1cde0;--text-tertiary:#8fa0b8;--text-muted:#8fa0b8;--text-disabled:#6b7d96;--text-inverse:#0f172a;--accent-primary:#5b7bb5;--accent-primary-hover:#4a6a9e;--accent-primary-active:#3d5a88;--accent-subtle:rgba(91,123,181,0.12);--accent-muted:rgba(91,123,181,0.06);--accent-primary-alpha:rgba(91,123,181,0.15);--accent-coscientist:#d4a039;--accent-coscientist-hover:#c4912e;--accent-coscientist-subtle:rgba(212,160,57,0.12);--accent-coscientist-border:rgba(212,160,57,0.30);--accent-coscientist-alpha:rgba(212,160,57,0.15);--accent-mode:#10b981;--accent-mode-subtle:rgba(16,185,129,0.12);--accent-mode-border:rgba(16,185,129,0.30);--accent-reasoning:#8b7cf8;--accent-reasoning-subtle:rgba(139,124,248,0.10);--accent-reasoning-border:rgba(139,124,248,0.25);--overlay-backdrop:rgba(0,0,0,0.6);--overlay-hero:rgba(11,15,20,0.3);--brand-red:#ef3d25;--border-primary:#1e293b;--border-secondary:#334155;--border-tertiary:#475569;--border-focus:var(--accent-primary);--status-success:#10b981;--status-success-bg:rgba(16,185,129,0.12);--status-success-border:rgba(16,185,129,0.3);--status-warning:#f59e0b;--status-warning-bg:rgba(245,158,11,0.12);--status-warning-border:rgba(245,158,11,0.3);--status-error:#ef4444;--status-error-bg:rgba(239,68,68,0.12);--status-error-border:rgba(239,68,68,0.3);--status-info:#06b6d4;--status-info-bg:rgba(6,182,212,0.12);--status-info-border:rgba(6,182,212,0.3);--shadow-xs:0 1px 2px 0 rgba(0,0,0,0.3);--shadow-sm:0 1px 3px 0 rgba(0,0,0,0.4),0 1px 2px -1px rgba(0,0,0,0.4);--shadow-md:0 4px 6px -1px rgba(0,0,0,0.4),0 2px 4px -2px rgba(0,0,0,0.4);--shadow-lg:0 10px 15px -3px rgba(0,0,0,0.5),0 4px 6px -4px rgba(0,0,0,0.5);--shadow-xl:0 20px 25px -5px rgba(0,0,0,0.5),0 8px 10px -6px rgba(0,0,0,0.5);--shadow-2xl:0 25px 50px -12px rgba(0,0,0,0.6);--shadow-inner:inset 0 2px 4px 0 rgba(0,0,0,0.3);--glow-primary:0 0 20px rgba(91,123,181,0.25);--glow-success:0 0 20px rgba(16,185,129,0.4);--glow-warning:0 0 20px rgba(245,158,11,0.4);--glow-error:0 0 20px rgba(239,68,68,0.4);--entity-gene:#10b981;--entity-gene-bg:rgba(16,185,129,0.12);--entity-gene-border:rgba(16,185,129,0.3);--entity-protein:#a78bfa;--entity-protein-bg:rgba(167,139,250,0.12);--entity-protein-border:rgba(167,139,250,0.3);--entity-molecule:#06b6d4;--entity-molecule-bg:rgba(6,182,212,0.12);--entity-molecule-border:rgba(6,182,212,0.3);--entity-pathway:#14b8a6;--entity-pathway-bg:rgba(20,184,166,0.12);--entity-pathway-border:rgba(20,184,166,0.3);--entity-drug:#f59e0b;--entity-drug-bg:rgba(245,158,11,0.12);--entity-drug-border:rgba(245,158,11,0.3);--entity-disease:#ef4444;--entity-disease-bg:rgba(239,68,68,0.12);--entity-disease-border:rgba(239,68,68,0.3);--entity-tissue:#ec4899;--entity-tissue-bg:rgba(236,72,153,0.12);--entity-tissue-border:rgba(236,72,153,0.3);--entity-trial:#60a5fa;--entity-trial-bg:rgba(96,165,250,0.12);--entity-trial-border:rgba(96,165,250,0.3);--entity-biomarker:#fb923c;--entity-biomarker-bg:rgba(251,146,60,0.12);--entity-biomarker-border:rgba(251,146,60,0.3);--font-sans:"DM Sans",-apple-system,BlinkMacSystemFont,"Segoe UI",sans-serif;--font-display:"Plus Jakarta Sans","DM Sans",-apple-system,sans-serif;--font-mono:"Cascadia Code","SF Mono",Consolas,"Liberation Mono",Menlo,monospace;--font-xs:0.8rem;--font-sm:0.875rem;--font-md:1rem;--font-body:1rem;--font-lg:1.25rem;--font-xl:1.563rem;--font-2xl:1.953rem;--font-h3:1.563rem;--font-h2:1.953rem;--font-h1:2.441rem;--font-size-display:3.052rem;--font-code:0.875rem;--font-base:1rem;--font-weight-normal:400;--font-weight-regular:400;--font-weight-medium:500;--font-weight-semibold:600;--font-weight-bold:700;--line-height-tight:1.2;--line-height-normal:1.5;--line-height-relaxed:1.625;--line-height-loose:2;--text-sm:var(--font-sm);--text-base:var(--font-body);--text-lg:var(--font-lg);--space-xs:var(--spacing-2);--space-sm:var(--spacing-3);--space-md:var(--spacing-4);--space-lg:var(--spacing-6);--space-xl:var(--spacing-8);--letter-spacing-tight:-0.01em;--letter-spacing-normal:0;--letter-spacing-wide:0.025em;--letter-spacing-wider:0.05em;--spacing-0:0;--spacing-1:0.25rem;--spacing-2:0.5rem;--spacing-3:0.75rem;--spacing-4:1rem;--spacing-5:1.25rem;--spacing-6:1.5rem;--spacing-8:2rem;--spacing-10:2.5rem;--spacing-12:3rem;--spacing-16:4rem;--spacing-20:5rem;--spacing-24:6rem;--radius-xs:0.25rem;--radius-sm:0.375rem;--radius-md:0.5rem;--radius-lg:0.75rem;--radius-xl:1rem;--radius-2xl:1.5rem;--radius-full:9999px;--duration-instant:0.1s;--duration-fast:0.15s;--duration-normal:0.25s;--duration-slow:0.3s;--duration-slower:0.4s;--ease-standard:cubic-bezier(0.4,0,0.2,1);--ease-decelerate:cubic-bezier(0.0,0,0.2,1);--ease-accelerate:cubic-bezier(0.4,0,1,1);--ease-bounce:cubic-bezier(0.68,-0.55,0.265,1.55);--transition-fast:var(--duration-fast) var(--ease-standard);--transition-normal:var(--duration-normal) var(--ease-standard);--transition-slow:var(--duration-slow) var(--ease-standard);--touch-target:44px;--touch-target-sm:36px;--touch-target-lg:56px;--container-sm:640px;--container-md:768px;--container-lg:1024px;--container-xl:1280px;--container-2xl:1536px;--sidebar-width:280px;--sidebar-collapsed:64px;--header-height:64px;--header-height-mobile:56px;--input-min-height:44px;--input-max-height:160px;--container-content:72rem;--container-page:80rem;--measure-body:68ch;--z-base:0;--z-header:50;--z-input:30;--z-floating:40;--z-kg-bar:25;--z-dropdown:70;--z-panel:90;--z-sidebar-overlay:99;--z-sidebar:100;--z-modal:110;--z-toast:120;--z-tooltip:130;--z-overlay-high:200;--breakpoint-xs:480px;--breakpoint-sm:640px;--breakpoint-md:768px;--breakpoint-lg:1024px;--breakpoint-xl:1280px;--breakpoint-2xl:1536px;--opacity-disabled:0.4;--opacity-muted:0.6;--opacity-hover:0.8;--opacity-full:1;--backdrop-blur-sm:blur(4px);--backdrop-blur-md:blur(8px);--backdrop-blur-lg:blur(12px);--backdrop-blur-xl:blur(16px)}[data-theme=light]{--bg-app:#f8fafc;--bg-primary:#ffffff;--bg-secondary:#f1f5f9;--bg-tertiary:#e2e8f0;--bg-hover:#f1f5f9;--bg-active:#e2e8f0;--text-primary:#0f172a;--text-secondary:#334155;--text-tertiary:#525c6b;--text-muted:#525c6b;--text-disabled:#64748b;--text-inverse:#f8fafc;--accent-primary:#3b5ea0;--accent-primary-hover:#2f4f8a;--accent-primary-active:#264175;--accent-subtle:rgba(59,94,160,0.08);--accent-muted:rgba(59,94,160,0.04);--accent-primary-alpha:rgba(59,94,160,0.15);--accent-coscientist:#b8881e;--accent-coscientist-hover:#a47a18;--accent-coscientist-subtle:rgba(184,136,30,0.08);--accent-coscientist-border:rgba(184,136,30,0.25);--accent-coscientist-alpha:rgba(184,136,30,0.12);--accent-mode:#059669;--accent-mode-subtle:rgba(5,150,105,0.08);--accent-mode-border:rgba(5,150,105,0.25);--accent-reasoning:#6d59e8;--accent-reasoning-subtle:rgba(109,89,232,0.08);--accent-reasoning-border:rgba(109,89,232,0.20);--overlay-backdrop:rgba(0,0,0,0.4);--overlay-hero:rgba(248,250,252,0.3);--border-primary:#e2e8f0;--border-secondary:#cbd5e1;--border-tertiary:#94a3b8;--shadow-xs:0 1px 2px 0 rgba(0,0,0,0.05);--shadow-sm:0 1px 3px 0 rgba(0,0,0,0.08),0 1px 2px -1px rgba(0,0,0,0.08);--shadow-md:0 4px 6px -1px rgba(0,0,0,0.08),0 2px 4px -2px rgba(0,0,0,0.06);--shadow-lg:0 10px 15px -3px rgba(0,0,0,0.08),0 4px 6px -4px rgba(0,0,0,0.06);--shadow-xl:0 20px 25px -5px rgba(0,0,0,0.08),0 8px 10px -6px rgba(0,0,0,0.06);--shadow-2xl:0 25px 50px -12px rgba(0,0,0,0.15);--shadow-inner:inset 0 2px 4px 0 rgba(0,0,0,0.04);--glow-primary:0 0 20px rgba(59,94,160,0.12);--glow-success:0 0 20px rgba(16,185,129,0.15);--glow-warning:0 0 20px rgba(245,158,11,0.15);--glow-error:0 0 20px rgba(239,68,68,0.15);--entity-gene:#059669;--entity-gene-bg:rgba(5,150,105,0.08);--entity-gene-border:rgba(5,150,105,0.25);--entity-protein:#7c3aed;--entity-protein-bg:rgba(124,58,237,0.08);--entity-protein-border:rgba(124,58,237,0.25);--entity-molecule:#0891b2;--entity-molecule-bg:rgba(8,145,178,0.08);--entity-molecule-border:rgba(8,145,178,0.25);--entity-pathway:#0d9488;--entity-pathway-bg:rgba(13,148,136,0.08);--entity-pathway-border:rgba(13,148,136,0.25);--entity-drug:#d97706;--entity-drug-bg:rgba(217,119,6,0.08);--entity-drug-border:rgba(217,119,6,0.25);--entity-disease:#dc2626;--entity-disease-bg:rgba(220,38,38,0.08);--entity-disease-border:rgba(220,38,38,0.25);--entity-tissue:#db2777;--entity-tissue-bg:rgba(219,39,119,0.08);--entity-tissue-border:rgba(219,39,119,0.25);--entity-trial:#2563eb;--entity-trial-bg:rgba(37,99,235,0.08);--entity-trial-border:rgba(37,99,235,0.25);--entity-biomarker:#ea580c;--entity-biomarker-bg:rgba(234,88,12,0.08);--entity-biomarker-border:rgba(234,88,12,0.25);--status-success:#047857;--status-warning:#b45309;--status-info:#0369a1;--status-success-bg:rgba(16,185,129,0.10);--status-warning-bg:rgba(245,158,11,0.10);--status-error-bg:rgba(239,68,68,0.10);--status-info-bg:rgba(6,182,212,0.10);--status-success-border:rgba(16,185,129,0.35);--status-warning-border:rgba(245,158,11,0.35);--status-error-border:rgba(239,68,68,0.35);--status-info-border:rgba(6,182,212,0.35)}@media (prefers-contrast:high){:root{--border-primary:#475569;--border-secondary:#64748b;--text-secondary:#dce6f0;--text-muted:#a8bacf}}@media (prefers-reduced-motion:reduce){:root{--duration-instant:0.01s;--duration-fast:0.01s;--duration-normal:0.01s;--duration-slow:0.01s;--duration-slower:0.01s}}@media (max-width:767px){:root{--font-size-display:2.441rem;--font-h1:1.953rem;--font-h2:1.563rem;--font-h3:1.25rem}}